Sievers 500 RL On-Line TOC Analyzer

Reliable, accurate performance for online TOC monitoring and real-time testing

Used extensively in the pharmaceutical industry, the Sievers 500 RL On-Line TOC Analyzer offers unmatched stability and performance. It provides online TOC analysis for compliance with USP <643> and other global pharmacopeia and can be provided with the critical protocols required for real-time testing (RTT) process validation. Specific features are offered for pharmaceutical applications, such as automated validation and system suitability testing, the ability to measure USP <645> conductivity, and compliance with 21 CFR Part 11. The 500 RL uses the most robust analytical technology available and is easy to implement and maintain.

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Learn about the NEW Sievers M500/e TOC Analyzers

NEW Sievers M500

Pharmaceutical Industry Compliance

The Sievers 500 RL is engineered to meet stringent global regulatory requirements in the pharmaceutical industry, including USP <643>, EP 2.2.44 Total Organic Carbon, IP 2.4.30, CP Appendix VIII R, and JP16 2.59 monographs for Purified Water and Water for Injection. Sievers DataGuard software facilitates compliance with 21 CFR Part 11.

Features & Benefits
Specifications

Features & Benefits

M500 Online Features & Benefits

Accuracy. Efficiency. Integrity.

150% faster analysis time
Advanced communications: Ethernet, WiFi, 4-20mA, Modbus, and Serial connectivity
10-inch color touchscreen
Super iOS 4-port sampler automates grad samples to improve productivity
Simultaneous TOC & conductivity measurement
Automated system suitability calibration, & validation
50% faster validation protocols
IP55 & full IP connections
Same footprint as 500 RL for easy upgrades

Specifications

M500 Online Specifications

Total Organic Carbon
Linear Range	0.03 to 2,500 ppb as TOC
Accuracy	± 5% of measurement; ±0.1 ppb
Precision	± 1% of measurement; ±0.3 ppb
pH Range	5.5 to 8.0 in order to meet accuracy specification
Analysis Modes	On-line, on-line averaged, on-line timed, Grab
Analysis Time^1,2	3 minutes for continuous online measurements
Ozone Compatibility	50 ppb O₃continuous; 200 ppb 0₃ for 2 hours daily
External Flow Rate	Minimum 50 mL/min
Sample Temperature	1–95 °C (34–203 °F) (withstands short-term exposure)
Sample Pressure	Up to 100 psig
Interferences	Insensitive to organic heteroatoms
Calibration Stability	Typically stable for 12 months
Display Readout	3 significant digits
Conductivity
Raw Conductivity Range	0.01 to 800 µS/cm
Conductivity Accuracy	0.005 µS/cm or 1%, whichever is greater
Conductivity Precision	<1.0% RSD
Instrument
Power Requirements	100–240 VAC, 70 W, 50/60 Hz
Fuses	No user-replaceable fuses
Normal Operating Environment	Intended for indoor use only
Ambient Temperature	5–40°C (41–104°F)
Maximum Relative Humidity	Up to 95%, noncondensing
Maximum Altitude	3,000 m (9,843 ft)
Inputs	Two isolated binary inputs
Outputs	Serial (RS-232), one USB, three 40-20 mA, four alarms, one Ethernet
Installation/Overvoltage	II (protects against transients present in Category II power)
Safety Certifications	CE, ETL listed. Conforms to UL Std. 61010-1. Certified to CSA 22.2 No. 61010-1.
Pollution Degree	2 (normally only non-conductive pollution)
Display	Backlit 10.1", 1280x800, touchscreen display
Size	H: 43.4 cm (17.1 in); W: 55.9 cm (22.0 in); D: 28.7 cm (11.3 in)
Weight	16.3 kg (36 lb)
IP Rating	IP 55
Optional Wi-Fi	802.11ac/a/b/g/n Dual-band 2.4/5 GHz
Industrial Communications Protocol	Modbus TCP/IP

¹Time to first measurement is 10 minutes

²Base model analysis time is six minutes for continuous online measurement

Learn how the 500 RL makes online TOC analysis in pharma easier